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Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)

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Each time the dose increases, expect 3-7 days of reduced appetite and possible nausea, similar to mild food poisoning